Class 6 - Division 6.1, Classification of Toxic Mixtures

If LC50 data is available, use the provided formulas in the classification section of the regulations to determine the estimated LC50 value of the mixture, the estimated volatility of each component, and the ration of volatility to the LC50. If LC50 data is not available, use the packing group criteria listed.

To determine the oral and dermal toxicity of a mixture and classify it into the appropriate packing group, you must first determine the acute LD50 of the mixture:

• If there is only one active substance, you can calculate the LD50 of the mixture by taking the LD50 value of the active substance and multiplying it by 100. Then, divide that answer by the percentage of the active substance by mass.
• If a mixture contains more than one active substance, there are three possible approaches for determining the oral and dermal toxicity:
  • Obtain acute oral and dermal toxicity data on the mixture.
  • Classify the mixture according to the most hazardous substance of the mixture.
  • Use the formula provided in the classification section of the regulations.

The LD50 toxicity data for common pesticides may be obtained from the World Health Organization (WHO) Recommended Classification of Pesticides by Hazard. Use only that document to obtain the LD50 value.

Examples of Division 6.1 toxic substances include the following:

• Tear gas
• Pesticides
• Hydrocyanic acid
• Carbon tetrachloride
• Toxic dyes
• Chloroform

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